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Targeting motor cortex high-excitability states defined by functional connectivity with real-time EEG–TMS
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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NeuroImage, Volume 284
Abstract
We tested previous post-hoc findings indicating a relationship between functional connectivity (FC) in the motor network and corticospinal excitability (CsE), in a real-time EEG-TMS experiment in healthy participants. We hypothesized that high FC between left and right motor cortex predicts high CsE. FC was quantified in real-time by single-trial phase-locking value (stPLV), and TMS single pulses were delivered based on the current FC. CsE was indexed by motor-evoked potential (MEP) amplitude in a hand muscle. Possible confounding factors (pre-stimulus μ-power and phase, interstimulus interval) were evaluated post hoc. MEPs were significantly larger during high FC compared to low FC. Post hoc analysis revealed that the FC condition showed a significant interaction with μ-power in the stimulated hemisphere. Further, inter-stimulus interval (ISI) interacted with high vs. low FC conditions. In summary, FC was confirmed to be predictive of CsE, but should not be considered in isolation from μ-power and ISI. Moreover, FC was complementary to μ-phase in predicting CsE. Motor network FC is another marker of real-time accessible CsE beyond previously established markers, in particular phase and power of the μ rhythm, and may help define a more robust composite biomarker of high/low excitability states of human motor cortex.
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Funding Information: This study is part of the Connect-to-brain project that has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant agreement No. 810377). The work by T. Mutanen has been supported by the Academy of Finland (Grant No. 321631) and the Finnish Foundation for Technology Promotion. Publisher Copyright: © 2023 The Author(s) | openaire: EC/H2020/810377/EU//ConnectToBrain
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Vetter, D E, Zrenner, C, Belardinelli, P, Mutanen, T P, Kozák, G, Marzetti, L & Ziemann, U 2023, 'Targeting motor cortex high-excitability states defined by functional connectivity with real-time EEG–TMS', NeuroImage, vol. 284, 120427. https://doi.org/10.1016/j.neuroimage.2023.120427