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Left hemisphere enhancement of auditory activation in language impaired children
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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11
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Scientific Reports, Volume 9, issue 1, pp. 1-11
Abstract
Specific language impairment (SLI) is a developmental disorder linked to deficient auditory processing. In this magnetoencephalography (MEG) study we investigated a specific prolonged auditory response (N250m) that has been reported predominantly in children and is associated with level of language skills. We recorded auditory responses evoked by sine-wave tones presented alternately to the right and left ear of 9–10-year-old children with SLI (n = 10) and children with typical language development (n = 10). Source analysis was used to isolate the N250m response in the left and right hemisphere. In children with language impairment left-hemisphere N250m responses were enhanced compared to those of controls, while no group difference was found in the right hemisphere. Consequently, language impaired children lacked the typical right-ward asymmetry that was found in control children. Furthermore, left but not right hemisphere N250m responses correlated positively with performance on a phonological processing task in the SLI group exclusively, possibly signifying a compensatory mechanism for delayed maturation of language processing. These results suggest that enhanced left-hemisphere auditory activation reflects a core neurophysiological manifestation of developmental language disorders, and emphasize the relevance of this developmentally specific activation pattern for competent language development.
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| openaire: EC/H2020/641652/EU//ChildBrain
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van Bijnen, S, Kärkkäinen, S, Helenius, P & Parviainen, T 2019, 'Left hemisphere enhancement of auditory activation in language impaired children', Scientific Reports, vol. 9, no. 1, 9087, pp. 1-11. https://doi.org/10.1038/s41598-019-45597-y