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Archaeal protein annotation
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Kemian tekniikan korkeakoulu |
Bachelor's thesis
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CHEM3054
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en
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34
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Abstract
Methanogenic archaea possess several metabolic traits of significant interest for applications, such as the ability to valorise CO2 using H2 as an energy source. However, the genes encoding metabolic enzymes in methanogenic archaea are still poorly understood. This thesis focuses on the functional annotation of proteins in methanogenic archaea. Using state-of-the-art bioinformatics tools, the proteomes of three methanogenic archaeal species were annotated. The results of these annotations were evaluated in terms of input protein sequence coverage, the number of identified metabolic enzymes, and the overlap between automatically annotated metabolic enzymes and those included in genome-scale metabolic models for two of the three species. The study also highlighted key challenges in archaeal protein functional annotation, such as high number of hypothetical proteins and limited experimental data. The findings emphasize the need for improved techniques and more experimental data to enhance protein function predictions in these understudied organisms.